Blar i forfatter "Opitz, Christiane A."

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    • G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling 

      Prentzell, Mirja Tamara; Rehbein, Ulrike; Sandoval, Marti Cadena; De Meulemeester, Ann-Sofie; Baumeister, Ralf; Brohée, Laura; Berdel, Bianca; Bockwoldt, Mathias; Carroll, Bernadette; Chowdhury, Suvagata Roy; von Deimling, Andreas; Demetriades, Constantinos; Figlia, Gianluca; de Arauj, Mariana Eca Guimaraes; Heberle, Alexander Martin; Heiland, Ines; Holzwarth, Birgit; Huber, Lukas A; Jaworski, Jacek; Kedra, Magdalena; Kern, Katharina; Kopach, Andrii; Korolchuk, Viktor I; van't Land-Kuper, Ineke; Macias, Matylda; Nellist, Mark; Palm, Wilhelm; Pusch, Stefan; Ramos Pittol, Jose Miguel; Reil, Michèle; Reintjes, Anja; Reuter, Friederike; Sampson, Julian R.; Scheldeman, Chloë; Siekierska, Aleksandra; Stefan, Eduard; Teleman, Aurelio A; Thomas, Laura E; Torres-Quesada, Omar; Trump, Saskia; West, Hannah D; de Witte, Peter; Woltering, Sandra; Yordanov, Teodor E; Zmorzynska, Justyna; Opitz, Christiane A.; Thedieck, Kathrin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-25)
      Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor the tuberous sclerosis complex (TSC) protein complex to lysosomes and suppress activation of the metabolic master regulator mechanistic ...

    • Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma 

      Mohapatra, Soumya R.; Sadik, Ahmed; Tykocinski, Lars-Oliver; Dietze, Jørn; Poschet, Gernot; Heiland, Ines; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-04)
      Abnormal circulation in solid tumors results in hypoxia, which modulates both tumor intrinsic malignant properties as well as anti-tumor immune responses. Given the importance of hypoxia in glioblastoma (GBM) biology and particularly in shaping anti-tumor immunity, we analyzed which immunomodulatory genes are differentially regulated in response to hypoxia in GBM cells. Gene expression analyses ...

    • Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production 

      Mohapatra, Soumya R; Sadik, Ahmed; Sharma, Suraj; Poschet, Gernot; Gegner, Hagen M; Lanz, Tobias V; Lucarelli, Philippe; Klingmüller, Ursula; Platten, Michael; Heiland, Ines; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-19)
      The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppressive metabolites. In light of these roles of Trp and its metabolic products, maintaining homeostatic ...

    • The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner 

      Heberle, Alexander Martin; Razquin Navas, Patricia; Langelaar-Makkinje, Miriam; Kasack, Katharina; Sadik, Ahmed; Faessler, Erik; Hahn, Udo; Marx-Stoelting, Philip; Opitz, Christiane A.; Sers, Christine; Heiland, Ines; Schaeuble, Sascha; Thedieck, Kathrin (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
      All cells and organisms exhibit stress-coping mechanisms to ensure survival. Cytoplasmic protein-RNA assemblies termed stress granules are increasingly recognized to promote cellular survival under stress. Thus, they might represent tumor vulnerabilities that are currently poorly explored. The translation-inhibitory eIF2α kinases are established as main drivers of stress granule assembly. Using a ...

    • Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma 

      Sharma, Suraj; Heiland, Ines; Panitz, Verena; Koncarevic, Sasa; Sadik, Ahmed; Friedel, Dennis; Bausbacher, Tobias; Trump, Saskia; Farztdinov, Vadim; Schulz, Sandra; Sievers, Philipp; Schmidt, Stefan; Jürgenson, Ina; Jung, Stephan; Kuhn, Karsten; Pflüger, Irada; Wick, Antje; Pfänder, Pauline; Selzer, Stefan; Vollmuth, Philipp; Sahm, Felix; von deimling, Andreas; Hopf, Carsten; Schulz-Knappe, Peter; Pike, Ian; Platten, Michael; Wick, Wolfgang; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)
      Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better understanding of Trp metabolism is required.<p> <P>Methods: The combination of LC-MS/MS with chemical isobaric labeling enabled the simultaneous quantitative ...

    • Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation 

      Adam, Isabell; Dewi, Dyah L.; Mooiweer, Joram; Sadik, Ahmed; Mohapatra, Soumya R.; Berdel, Bianca; Keil, Melanie; Sonner, Jana K.; Thedieck, Kathrin; Rose, Adam J.; Platten, Michael; Heiland, Ines; Trump, Saskia; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-05)
      Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction. However, it remains unclear how tumor cells can proliferate while degrading the essential amino acid Trp. Trp is incorporated into proteins after it is attached to its tRNA by tryptophanyl-tRNA synthestases. As ...